Invited Speakers

  • Prof. Nik Maniatis, University College London
  • Dr Toby Andrew, Imperial College London
  • Dr Maria Secrier, University College London
  • Dr Igor Ruiz De Los Mozos, Francis Crick Institute

Symposium Co-Chairs:

  • Nikolas Maniatis, Professor of Human Genetics
  • Andrea Townsend-Nicholson, Professor of Biochemistry & Molecular Biology

Symposium Description

The sequencing of the human genome, published 50 years after the discovery of the structure of DNA, has had a paradigm-shifting impact on a broad range of disciplines. Today, advances in DNA sequencing technologies and in the computational processors, storage and analyses underpinning these have seen the cost of sequencing an individual’s genome drop to the levels needed for this technology to form part of a suite of healthcare tests. Future developments in DNA sequencing will make genome sequencing even less expensive, placing us well and truly in the post-genomic era of biomedicine.

Traditionally, genomics has been the area of biomedical research that was an early adopter of computational methodologies and has the highest concentration of computational biologists. Despite this, the widespread adoption of high performance computing resources remains the province of few researchers in the domain. In this symposium we shall examine the state-of-the-art in genomics research, how this has paved the way for new applications of molecular medicine and how high performance computing can inform applied genomics research to bring transformative changes to clinical practice and personalised medicine.

Wednesday 25th September, 13:30 – 15:30; Watson Watt Room

Time Speaker Title
13:30 Maria Secrier
(Invited Speaker)
Reconstructing mutational histories of oesophageal cancer
13:50 Igor Ruiz de Los Mozos
(Invited Speaker)
CDK11 binds chromatin and mRNAs of replication dependent histones regulating their expression.
14:10 Nik Maniatis
(Invited Speaker)
The power of high-resolution population-specific genetic maps to dissect the genetic architecture of complex diseases: Type 2 Diabetes as an example
14:30 Toby Andrew
(Invited Speaker)
Genetic fine-mapping and targeted sequencing to investigate allelic heterogeneity and molecular function at genomic disease susceptibility loci for Type 2 Diabetes
14:50 Hannah Maude Pathway analysis reveals genetic regulation of mitochondrial function and branched-chain amino acid catabolism in Type 2 Diabetes
15:00 Karoline Kuchenbaecker Trans-ethnic colocalization: A novel approach to assess the transferability of trait loci across populations
15:10 Julia Ramírez The Genetic Architecture of T-wave Morphology Restitution
15:20 Stefan van Diujvenboden Genetic architecture of QT dynamics and resting QT in the general population